Description

2-(1H-1,2,3-Benzotriazol-1-Yl)Ethanesulfonyl Fluoride is a specialized benzotriazole derivative featuring a reactive sulfonyl fluoride group. This compound is a critical building block in medicinal chemistry and chemical biology, primarily valued for its role as a key intermediate in the synthesis of covalent inhibitors and PROTACs (Proteolysis Targeting Chimeras). It is essential for research and development teams in the pharmaceutical and biotechnology sectors who require high-purity, reliable intermediates for constructing molecules that form irreversible bonds with target proteins.

Application

• Covalent Drug Discovery: A crucial electrophilic "warhead" for synthesizing irreversible inhibitors targeting various enzymes, including kinases and proteases.
• PROTAC Linker Chemistry: Used to construct the linker component that connects an E3 ligase ligand to a target protein ligand, enabling targeted protein degradation.
• Chemical Biology Probes: Serves as a reactive handle for creating activity-based probes (ABPs) to study enzyme function and activity in complex biological systems.
• Peptide and Protein Modification: Enables selective, irreversible labeling of proteins, peptides, and antibodies for bioconjugation applications.
• Material Science Intermediates: Can be utilized in the synthesis of advanced polymers and materials where benzotriazole and sulfonyl fluoride functionalities are required.

Basic Information

Product Name	2-(1H-1,2,3-Benzotriazol-1-Yl)Ethanesulfonyl Fluoride
CAS No.	71517-82-3
Molecular Formula	C8H8FN3O2S
Molecular Weight	229.23 g/mol
Synonyms	2-(1H-Benzotriazol-1-yl)ethanesulfonyl Fluoride; 1H-1,2,3-Benzotriazole-1-ethanesulfonyl Fluoride; BTF; Benzotriazole Ethyl Sulfonyl Fluoride; 2-(1H-1,2,3-Benzotriazol-1-yl)ethane-1-sulfonyl fluoride; 2-(1H-Benzotriazol-1-yl)ethanesulfonyl fluoride; 2-(1H-1,2,3-Benzotriazol-1-yl)ethanesulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 2-(1H-1,2,3-Benzotriazol-1-Yl)Ethanesulfonyl Fluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.