Description

Vinorelbine is a semi-synthetic vinca alkaloid antineoplastic agent, representing a critical component in modern oncology treatment regimens. Its primary value lies in its mechanism of action, which inhibits microtubule polymerization, thereby disrupting mitosis and leading to apoptosis in rapidly dividing cancer cells. This product is essential for pharmaceutical manufacturers and research institutions developing and producing chemotherapeutic formulations, particularly for the treatment of non-small cell lung cancer and advanced breast cancer. We supply high-purity Vinorelbine CAS NO 71486-22-1 to support global pharmaceutical development and manufacturing needs.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in injectable chemotherapy formulations.
• Oncology Drug Manufacturing: Production of branded and generic chemotherapeutic drugs, including single-agent therapies and combination regimens.
• Clinical Research & Development: Serves as a reference standard and raw material for preclinical studies and clinical trials investigating new cancer treatments.
• Non-Small Cell Lung Cancer (NSCLC) Therapy: A key component in first-line and subsequent treatment protocols for NSCLC.
• Advanced Breast Cancer Therapy: Used in the management of metastatic or recurrent breast cancer.
• Drug Discovery: Utilized in research to develop novel drug conjugates or explore new mechanisms of action for vinca alkaloids.
• Analytical Reference Standard: High-purity grade material for use in quality control laboratories for HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	Vinorelbine
CAS No.	71486-22-1
Molecular Formula	C45H54N4O8
Molecular Weight	778.94 g/mol
Synonyms	Vinorelbine Tartrate (common salt form); 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine; 5'-Noranhydrovinblastine; Navelbine® (Brand Name); KW-2307; Nor-5'-anhydrovinblastine; Didehydro-4-deoxy-C'-norvincaleukoblastine; (3α,4β,5α,12α,19α)-4-(Acetyloxy)-15-[(7S,9S)-7-ethyl-9-[(2R,6S,8S)-6-ethyl-1,3,6,7,8,9-hexahydro-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-7,8,9,10-tetrahydro-6,9-methano-5H-pyrido[3',4':4,5]cyclohepta[1,2-b]indol-11(6H)-yl]-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-16-azahexacyclo[10.6.1.01,9.02,7.012,17.014,19]nonadeca-2,7-diene-10-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Vinorelbine is manufactured and tested under strict quality systems to meet the exacting standards of the pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure compliance with relevant pharmacopeial specifications (e.g., USP, EP). A detailed Certificate of Analysis (COA) documenting purity, potency, and all critical quality attributes is provided with every shipment to guarantee traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, store under controlled room temperature conditions (typically 15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.