Description

Pinane-Thromboxane A2 is a stable, synthetic analog of the potent bioactive lipid mediator Thromboxane A2, incorporating a pinane ring structure for enhanced chemical stability. This compound serves as a critical research tool and a potential synthetic intermediate for investigating platelet aggregation, vasoconstriction, and related physiological pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on cardiovascular biology, hemostasis, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a stable reference standard and agonist in studies of thromboxane receptor (TP receptor) signaling and function.
• Pharmacological Development: Serves as a key intermediate or lead compound in the synthesis of thromboxane synthase inhibitors or receptor antagonists.
• Platelet Function Studies: Employed in in vitro assays to induce and study platelet aggregation and activation mechanisms.
• Vascular Biology Research: Applied in experiments to investigate vasoconstriction, smooth muscle cell proliferation, and related cardiovascular pathologies.
• Standards and Calibration: Used for the calibration of analytical equipment (HPLC, LC-MS) and as a quantitative standard in bioanalytical methods.
• Fine Chemical Synthesis: Acts as a specialized building block for the synthesis of more complex prostaglandin and thromboxane analogs.

Basic Information

Product Name	Pinane-Thromboxane A2
CAS No.	71154-83-1
Molecular Formula	C23H36O5
Molecular Weight	392.53 g/mol
Synonyms	9,11-Epoxy-15-hydroxy-10,10-dimethyl-5,13-prostadienoic acid; Pinane TXA2; (5Z,9α,11α,13E,15S)-9,11-Epoxy-15-hydroxy-10,10-dimethyl-5,13-prostadienoic acid; Thromboxane A2 Pinane Analog; STA2 (Pinane derivative); PTXA2; 15S-Hydroxy-10,10-dimethyl-δ5-9,11-epoxy-13-trans-prostadienoic Acid
EINECS	Contact for details

Quality Control

Our Pinane-Thromboxane A2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, ensuring compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and light-sensitive nature. For long-term storage, desiccants are recommended. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 5.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.