Description

(+/-)-Bay K 8644 CAS NO 71145-03-4 is a well-characterized calcium channel agonist, specifically a dihydropyridine derivative, used extensively in pharmacological research. This compound is a critical tool for modulating L-type voltage-gated calcium channels, enabling the study of calcium signaling pathways and their physiological roles. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for investigating cardiovascular function, neuronal activity, and endocrine secretion.

Application

• Pharmacological Research: A key reference standard and active agent in studies of L-type calcium channel function and modulation.
• Cardiovascular Studies: Used to investigate cardiac muscle contraction, vascular smooth muscle tone, and related disease models.
• Neuroscience Research: Employed to probe calcium-dependent neurotransmitter release, synaptic plasticity, and neuronal excitability.
• Endocrine System Research: Applied in studies of calcium-mediated hormone secretion from glands such as the adrenal medulla and pancreas.
• Cell Signaling Pathways: Serves as a precise tool to activate specific calcium influx pathways in various cell types for mechanistic studies.
• High-Throughput Screening (HTS): Used as a control compound in drug discovery campaigns targeting ion channels.

Basic Information

Product Name	(+/-)-Bay K 8644
CAS No.	71145-03-4
Molecular Formula	C22H23N3O6
Molecular Weight	425.44 g/mol
Synonyms	Bay K 8644; Methyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylate; (RS)-Bay K8644; (±)-Bay K 8644; 3-Nitro-2,6-dimethyl-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-5-carboxylic acid methyl ester; BAY-K-8644; LM-1504
EINECS	Contact for details

Quality Control

Our (+/-)-Bay K 8644 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.