Description

H-D-Phe-Pro-Arg-Chloromethylketone Trifluoroacetate Salt is a highly specific and potent irreversible inhibitor of serine proteases, particularly thrombin. This compound matters for researchers and manufacturers requiring precise biochemical control in complex enzymatic systems. It is primarily needed by the pharmaceutical, biotechnology, and life science research sectors for applications in drug discovery, proteomics, and the development of diagnostic assays.

Application

• Biochemical Research: As a critical tool compound for studying the structure, function, and inhibition mechanisms of serine proteases like thrombin, trypsin, and related enzymes.
• Pharmaceutical Development: Used in the research and screening stages for developing novel anticoagulant and antithrombotic therapeutic agents.
• Proteomics & Enzyme Kinetics: Employed to selectively inhibit specific proteases in complex biological samples, enabling detailed pathway analysis and kinetic studies.
• Diagnostic Reagent Formulation: Serves as a key component in the development of in-vitro diagnostic kits for coagulation disorders and related clinical tests.
• Cell Biology Studies: Utilized to investigate the role of specific proteases in cellular processes such as signaling, migration, and apoptosis.

Basic Information

Product Name	H-D-Phe-Pro-Arg-Chloromethylketone Trifluoroacetate Salt
CAS No.	71142-71-7
Molecular Formula	C30H38ClF3N8O6
Molecular Weight	699.12 g/mol
Synonyms	PPACK (D-Phe-Pro-Arg-CH2Cl); D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone trifluoroacetate; Thrombin Inhibitor I; PPACK-Thrombin Inhibitor; (D)Phe-Pro-Arg-CH2Cl; H-D-Phe-Pro-Arg-CH2Cl TFA; FPR Chloromethyl Ketone TFA Salt; FPRCK TFA
EINECS	Contact for details

Quality Control

Our H-D-Phe-Pro-Arg-Chloromethylketone Trifluoroacetate Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical and biochemical reagent production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.