Description

1-Bromomethyl-4-Fluoro-2-Iodo-Benzene is a versatile and highly functionalized halogenated benzene derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of three distinct halogens—bromine, fluorine, and iodine—which offer orthogonal reactivity for sequential cross-coupling and substitution reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules and developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine and bromine substituents make it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings for carbon-carbon bond formation.
• Radiolabeling Precursor: Potential use as a starting material for synthesizing compounds labeled with iodine-125 or other isotopes for diagnostic imaging and research.
• Ligand and Catalyst Development: Employed to create sophisticated ligands for asymmetric catalysis and organometallic complexes.

Basic Information

Product Name	1-Bromomethyl-4-Fluoro-2-Iodo-Benzene
CAS No.	70931-59-8
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	4-Fluoro-2-iodobenzyl Bromide; 2-Iodo-4-fluorobenzyl Bromide; (4-Fluoro-2-iodophenyl)methyl Bromide; α-Bromo-4-fluoro-2-iodotoluene; 1-(Bromomethyl)-4-fluoro-2-iodobenzene; Benzene, 1-(bromomethyl)-4-fluoro-2-iodo-; 70931-59-8; 4-Fluoro-2-iodo-benzylbromide
EINECS	Contact for details

Quality Control

Our 1-Bromomethyl-4-Fluoro-2-Iodo-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.