Description

o-Cresol-D3 is a deuterium-labeled isotopologue of ortho-cresol, a key compound in analytical chemistry and life science research. This high-purity labeled standard is essential for ensuring accuracy and reliability in quantitative mass spectrometry and metabolic studies, where it serves as an internal reference to correct for instrument variability and sample preparation losses. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) research, environmental analysis, and advanced organic synthesis.

Application

• Internal Standard for Quantitative Analysis: Used as a critical internal standard in Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) for the precise quantification of o-cresol and related phenolic compounds in complex matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Facilitates tracer studies to investigate the metabolic pathways, bioavailability, and excretion profiles of pharmaceutical compounds and environmental toxins.
• Environmental and Occupational Monitoring: Enables accurate measurement of cresol isomers in air, water, and biological samples for exposure assessment and regulatory compliance.
• Stable Isotope Labeling in Synthesis: Serves as a deuterated building block for the synthesis of more complex labeled molecules for use in mechanistic studies and as non-radioactive tracers.
• Quality Control & Method Development: Employed in analytical method development, validation, and routine quality control in chemical and pharmaceutical manufacturing to ensure method robustness.

Basic Information

Product Name	o-Cresol-D3
CAS No.	70837-27-3
Molecular Formula	C7H5D3O
Molecular Weight	111.15 g/mol
Synonyms	2-Methylphenol-d3; 2-Hydroxytoluene-d3; ortho-Cresol-d3; 1-Hydroxy-2-methylbenzene-d3; 2-Cresol-d3; o-Methylphenol-d3; (2H3)-o-Cresol; Deuterated o-cresol
EINECS	Contact for details

Quality Control

Our o-Cresol-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, GC-MS, and HPLC, to confirm identity, isotopic enrichment (typically >98 atom % D), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a well-ventilated area to maintain integrity and prevent contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.