Description

4-tert-Butyl-2,6-Dimethylbenzenesulfonyl Chloride is a specialized sulfonyl chloride derivative, a key intermediate in advanced organic synthesis. Its value lies in its role as a versatile sulfonylation reagent, enabling the introduction of the sterically hindered 4-tert-butyl-2,6-dimethylphenylsulfonyl group to create novel molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and fine chemicals where specific steric and electronic properties are required.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in creating sulfonamide-based active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the bulky sulfonyl moiety can enhance biological activity and selectivity.
• Polymer Chemistry: Serves as a monomer or modifying agent in the production of specialty polymers, including high-performance resins and materials with specific functional groups.
• Dye and Pigment Manufacturing: Employed in the synthesis of specialized dyes and pigments, where the sulfonyl chloride group facilitates attachment to chromophores.
• Ligand and Catalyst Development: Utilized for preparing sophisticated ligands for metal catalysis or as a precursor for functionalized materials in catalytic systems.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	4-tert-Butyl-2,6-Dimethylbenzenesulfonyl Chloride
CAS No.	70823-04-0
Molecular Formula	C12H17ClO2S
Molecular Weight	260.78 g/mol
Synonyms	2,6-Dimethyl-4-tert-butylbenzenesulfonyl chloride; 4-(tert-Butyl)-2,6-dimethylbenzenesulfonyl chloride; 1-tert-Butyl-3,5-dimethylbenzene-2-sulfonyl chloride; 2,6-Dimethyl-4-(1,1-dimethylethyl)benzenesulfonyl chloride; 4-tert-Butyl-2,6-dimethylphenylsulfonyl chloride; Mesitylene-4-sulfonyl chloride, 2-tert-butyl-; TBDMS-Cl (context-specific, not to be confused with tert-butyldimethylsilyl chloride)
EINECS	Contact for details

Quality Control

Our production of 4-tert-Butyl-2,6-Dimethylbenzenesulfonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including assay by titration or HPLC, identification by FT-IR and NMR, and control of key impurities and moisture content. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC/Titration)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.