Description

Monoiodoapamin is a chemically modified derivative of the bee venom peptide apamin, characterized by the specific iodination of a tyrosine residue. This modification is crucial for creating a high-affinity, radiolabeled ligand used extensively in biochemical and pharmacological research. It serves as an indispensable tool for scientists studying small-conductance calcium-activated potassium (SK) channels. Researchers in neuropharmacology, ion channel biology, and drug discovery rely on Monoiodoapamin CAS NO 70592-40-4 for receptor binding assays and detailed mapping studies.

Application

• SK Channel Research: Primary high-affinity ligand for binding and characterizing small-conductance calcium-activated potassium (SK) channels.
• Receptor Binding Assays: Used in competitive binding studies to screen and evaluate potential SK channel modulators and blockers.
• Neuroscience & Neuropharmacology: A key tool for investigating the role of SK channels in neuronal excitability, synaptic plasticity, and neurological disorders.
• Radioligand Preparation: Serves as the precursor for the synthesis of iodine-125 (125I) labeled apamin for autoradiography and advanced imaging studies.
• Drug Discovery & Development: Facilitates target validation and lead compound optimization in pipelines targeting SK channels for therapeutic intervention.
• Biochemical Tool Compound: Employed in laboratory settings to isolate, study, and understand the structure-function relationship of peptide-toxin interactions with ion channels.

Basic Information

Product Name	Monoiodoapamin
CAS No.	70592-40-4
Molecular Formula	C78H131IN26O24S4
Molecular Weight	2022.3 g/mol
Synonyms	3-Iodo-L-tyrosine-18-apamin; Iodoapamin; Apamin, 18-(3-iodo-L-tyrosine)-; Monoiodotyrosyl18-apamin; [Tyr(I)18]-Apamin; I125-Apamin precursor; SK channel ligand; Potassium channel blocker apamin derivative
EINECS	Contact for details

Quality Control

Every batch of Monoiodoapamin is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency for critical research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing comprehensive analytical results, including HPLC purity, mass spectrometry (MS) confirmation, and biological activity verification, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Iodination Confirmation (MS)	Present
Biological Activity (Binding Assay)	≥ 90% relative to reference
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.