Description

Methyl 4,4,4-Trifluorocrotonate is a high-value fluorinated building block, specifically an α,β-unsaturated ester, essential for introducing the trifluoromethyl group into complex molecular architectures. Its primary commercial value lies in enabling efficient synthesis routes for advanced agrochemicals and pharmaceuticals, where the CF3 moiety is critical for enhancing biological activity and metabolic stability. This compound is particularly sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential antiviral and anticancer agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for developing fluorinated polymers and specialty materials with unique surface properties.
• Organic Synthesis Building Block: Employed in Michael additions, cycloadditions, and other C-C bond-forming reactions to create complex, fluorinated organic molecules.
• Liquid Crystal & Electronic Chemical Precursor: Used in the research and development of fluorinated components for display and electronic applications.

Basic Information

Product Name	Methyl 4,4,4-Trifluorocrotonate
CAS No.	70577-95-6
Molecular Formula	C5H5F3O2
Molecular Weight	154.09 g/mol
Synonyms	Methyl 4,4,4-Trifluorobut-2-enoate; 4,4,4-Trifluorocrotonic Acid Methyl Ester; 2-Butenoic acid, 4,4,4-trifluoro-, methyl ester; Methyl (E)-4,4,4-trifluorocrotonate; Trifluorocrotonic acid methyl ester; Methyl β,β,β-trifluorocrotonate; Methyl 4,4,4-trifluoro-2-butenoate
EINECS	Contact for details

Quality Control

Our Methyl 4,4,4-Trifluorocrotonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Isomeric Purity (GC)	≥ 95.0% (typically E-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.