Description

Herbimycin A CAS NO 70563-58-5 is a potent benzoquinone ansamycin antibiotic and a well-characterized Hsp90 inhibitor. This compound is a critical research tool for studying cellular signaling pathways, particularly those involving tyrosine kinases and heat shock protein 90 (Hsp90) client proteins. It is primarily utilized by researchers and developers in the life sciences, pharmaceutical, and biotechnology sectors for target validation, mechanism-of-action studies, and as a reference standard in analytical workflows.

Application

• Biomedical Research: As a specific inhibitor of Hsp90, used to study protein folding, degradation, and the role of Hsp90 in cancer, neurodegenerative diseases, and other pathologies.
• Signal Transduction Studies: Employed to investigate and modulate tyrosine kinase signaling cascades, including those of Src-family kinases.
• Antibiotic Research: Serves as a model compound in studies of ansamycin-class antibiotics and their mechanisms of action.
• Pharmaceutical Development: Used as a reference standard and pharmacological tool in drug discovery programs targeting Hsp90 and related pathways.
• Cell Biology: Applied in cell culture experiments to induce specific phenotypic changes and understand chaperone-dependent cellular processes.
• Biochemical Assays: Utilized as a key reagent in in vitro enzymatic assays to validate the activity and specificity of Hsp90 inhibitors.

Basic Information

Product Name	Herbimycin A
CAS No.	70563-58-5
Molecular Formula	C30H42N2O9
Molecular Weight	574.67 g/mol
Synonyms	Herbimycin A; NSC 305978; Antibiotic Herbimycin A; 15-Deoxy-15,16-didehydro-17-demethoxy-17-(2-propenylamino)geldanamycin; 7-O-Carbamoyl-7-deoxygeldanamycin; Ansamycin antibiotic; Hsp90 Inhibitor I; Benzoquinone ansamycin
EINECS	Contact for details

Quality Control

Our Herbimycin A is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR, MS), and residual solvent analysis to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.