Description

(3α,5α)-21-Hydroxy-11,20-Dioxopregnan-3-Yl β-D-Glucopyranosiduronic Acid is a high-purity steroid glucuronide derivative, a key intermediate in advanced pharmaceutical synthesis and research. Its primary value lies in its role as a crucial metabolite and reference standard for the study of steroid hormone pathways and drug metabolism. This compound is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) requiring precise and reliable biochemical intermediates.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of steroid metabolites in bioanalytical methods like LC-MS/MS.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Serves as a critical metabolite standard for investigating the biotransformation, excretion, and pharmacokinetic profiles of related steroid-based pharmaceuticals.
• Biochemical Research: Employed in enzymatic and receptor-binding studies to understand steroid hormone conjugation, transport, and elimination mechanisms.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a sophisticated synthetic building block in the multi-step production of specialized steroid drugs.
• Diagnostic Kit Manufacturing: Utilized in the development and calibration of immunoassays and diagnostic tests for hormonal balance and endocrine function.

Basic Information

Product Name	(3α,5α)-21-Hydroxy-11,20-Dioxopregnan-3-Yl β-D-Glucopyranosiduronic Acid
CAS No.	70522-56-4
Molecular Formula	C27H40O10
Molecular Weight	524.60 g/mol
Synonyms	21-Hydroxy-11,20-dioxopregnan-3-yl β-D-glucopyranosiduronic acid; 11,20-Dioxopregnane-3,21-diol 3-(β-D-Glucuronide); Tetrahydrocorticosterone 3-Glucuronide; 5α-Pregnane-3α,21-diol-11,20-dione 3-glucuronide; THB 3-Glucuronide; 3α,21-Dihydroxy-5α-pregnane-11,20-dione 3-glucuronide; (3α,5α)-Pregnan-21-ol-11,20-dione 3-(β-D-glucopyranosiduronic acid)
EINECS	Contact for details

Quality Control

Every batch of (3α,5α)-21-Hydroxy-11,20-Dioxopregnan-3-Yl β-D-Glucopyranosiduronic Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results from advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.