Description

Codeine-D3 is a deuterium-labeled isotopologue of codeine, a naturally occurring opiate alkaloid, specifically identified by CAS NO 70420-71-2. This stable isotope-labeled compound is essential as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and clinical research sectors who require definitive analytical precision.

Application

• Pharmaceutical Research & Development: Serves as a critical internal standard for the precise quantification of codeine and its metabolites in pharmacokinetic, bioavailability, and bioequivalence studies.
• Forensic and Clinical Toxicology: Enables accurate and legally defensible analysis of codeine in biological matrices (e.g., blood, urine) for drug testing, overdose cases, and compliance monitoring.
• Metabolite Pathway Analysis: Used in advanced LC-MS/MS and GC-MS methodologies to study the metabolic fate and biotransformation pathways of codeine in vivo.
• Quality Control & Assurance: Employed in pharmaceutical manufacturing QC labs to validate analytical methods and ensure the accurate assay of codeine in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Reference Standard Production: Acts as a certified reference material (CRM) for calibrating instruments and developing validated analytical protocols in compliance with GLP and ISO 17025.

Basic Information

Product Name	Codeine-D3
CAS No.	70420-71-2
Molecular Formula	C18H18D3NO3
Molecular Weight	302.39 g/mol
Synonyms	Codeine-methyl-d3; 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol-methyl-d3; (5α,6α)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol-methyl-d3; Morphine-3-methyl ether-d3; Codicept-d3; 3-Methylmorphine-d3; Deuterated Codeine Internal Standard
EINECS	Contact for details

Quality Control

Our Codeine-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity by HPLC, and confirmation of structure. We adhere to standards relevant for high-purity reference materials to guarantee reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.