Description

4-Hydroxyalprenolol Glucuronide is a key metabolite of the β-blocker drug alprenolol, formed via the glucuronidation pathway. This compound is of significant importance in pharmaceutical research and development, particularly for drug metabolism and pharmacokinetic (DMPK) studies. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and regulatory toxicology assessments.

Application

• Reference Standard for Bioanalysis: Serves as a critical certified reference material (CRM) for the quantitative analysis of alprenolol and its metabolites in biological matrices (e.g., plasma, urine) using LC-MS/MS or HPLC.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in in vitro and in vivo studies to understand the metabolic fate, clearance pathways, and excretion profile of alprenolol.
• Metabolite Synthesis & Characterization: Acts as a synthetic intermediate or a characterized standard for producing and identifying other related phase II metabolites.
• Toxicology and Safety Assessment: Employed in safety testing to evaluate the potential biological activity and toxicity of alprenolol metabolites.
• Enzyme Activity Studies: Useful in research focused on UDP-glucuronosyltransferase (UGT) enzyme kinetics and specificity.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized as an impurity standard to monitor and control the quality of alprenolol active pharmaceutical ingredient (API).

Basic Information

Product Name	4-Hydroxyalprenolol Glucuronide
CAS No.	70359-54-5
Molecular Formula	C22H33NO9
Molecular Weight	455.50 g/mol
Synonyms	4-Hydroxyalprenolol β-D-Glucuronide; Alprenolol Hydroxy Glucuronide; 1-[2-(Allyloxy)-3-[(1-methylethyl)amino]propoxy]-4-hydroxybenzene β-D-Glucopyranosiduronic Acid; 4-Hydroxyalprenolol Glucuronide; Alprenolol Metabolite Glucuronide; 4-Hydroxy Alprenolol Glucuronide; 4'-Hydroxyalprenolol Glucuronide
EINECS	Contact for details

Quality Control

Our 4-Hydroxyalprenolol Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.