Description

12-Deoxyphorbol-13-Decanoate is a specific ester derivative of the phorbol diterpene core, known for its role as a reference standard and a key intermediate in biochemical research. This compound is critical for scientists investigating protein kinase C (PKC) signaling pathways and the structure-activity relationships of phorbol esters. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for analytical, pharmacological, and synthetic applications.

Application

• Biochemical Research Standard: Serves as a high-purity reference material for calibrating analytical instruments and validating assay methods in PKC-related studies.
• Pharmacological Studies: Used as a tool compound to investigate the modulation of protein kinase C activity and its downstream cellular effects.
• Structure-Activity Relationship (SAR) Analysis: Acts as a crucial intermediate or analog for synthesizing and evaluating modified phorbol esters to understand their biological potency and selectivity.
• Academic & Industrial R&D: Employed in university and corporate laboratories for fundamental research into cell signaling, tumor promotion mechanisms, and drug discovery programs.
• Analytical Method Development: Used as a known compound to develop and optimize chromatographic (e.g., HPLC, LC-MS) separation and detection protocols.

Basic Information

Product Name	12-Deoxyphorbol-13-Decanoate
CAS No.	70278-05-6
Molecular Formula	C30H46O6
Molecular Weight	502.69 g/mol
Synonyms	12-Deoxyphorbol 13-decanoate; Phorbol-13-decanoate, 12-deoxy-; 12-DPD; 13-Decanoate of 12-deoxyphorbol; 4,9,12,13-Tetrahydroxy-1,6-tigliadien-3-one 13-decanoate; 12-Deoxyphorbol 13-n-decanoate; Deoxyphorbol decanoate; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Decanoyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b,9-trihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl decanoate
EINECS	Contact for details

Quality Control

Our 12-Deoxyphorbol-13-Decanoate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.