Description

Pimonidazole CAS NO 70132-51-3 is a nitroimidazole derivative widely recognized as a vital chemical marker for hypoxia in biological research. Its primary value lies in its selective bioreductive binding to macromolecules in cells with low oxygen concentration, enabling the detection and quantification of hypoxic regions. This compound is essential for researchers and developers in the fields of oncology, radiobiology, and drug discovery, where understanding tumor microenvironment and treatment efficacy is critical. Its reliable performance makes it a cornerstone reagent for advancing therapeutic strategies and diagnostic applications.

Application

• Hypoxia Marker in Biomedical Research: Used extensively as a chemical probe to identify and quantify hypoxic cells in tumor sections and other tissues.
• Preclinical Oncology Studies: Employed in cancer research to assess tumor hypoxia, a key factor influencing radiation therapy and chemotherapy resistance.
• Radiobiology Investigations: Applied to study the relationship between oxygen levels and the effectiveness of radiotherapy.
• Drug Development & Screening: Serves as a tool in pharmaceutical R&D for evaluating the hypoxic targeting of novel therapeutic agents.
• Diagnostic Reagent Formulation: Utilized in the development of diagnostic kits and assays for hypoxia detection.
• Mechanistic Studies in Pathophysiology: Aids in research on diseases where hypoxia plays a role, such as cardiovascular conditions and stroke.

Basic Information

Product Name	Pimonidazole
CAS No.	70132-51-3
Molecular Formula	C₁₂H₁₈N₄O₃
Molecular Weight	266.30 g/mol
Synonyms	1-[(2-Hydroxy-3-piperidinyl)propyl]-2-nitroimidazole; Ro 03-8799; Pimonidazole Hydrochloride (common salt form); Hypoxyprobe™-1 (trade name); Hypoxia Marker Pimonidazole; 2-Nitro-1-[(2-hydroxy-3-piperidino)propyl]imidazole; NSC 684681
EINECS	Contact for details

Quality Control

Our Pimonidazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity determination by HPLC. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.