Description

(8S)-4-o-Ethyltetrodotoxin is a potent neurotoxin and a semi-synthetic derivative of tetrodotoxin (TTX). This compound is of significant interest in advanced neuroscience research and pharmacological studies due to its specific and high-affinity blockade of voltage-gated sodium channels. It is primarily utilized by research institutions, pharmaceutical R&D departments, and specialized chemical suppliers focusing on neuroactive compounds for applications in electrophysiology, toxin research, and the development of novel analgesic pathways.

Application

• Neuroscience Research: As a highly specific sodium channel blocker for electrophysiological studies to understand neuronal signaling and action potential generation.
• Pharmacological Tool Compound: Used in vitro and in vivo to investigate pain pathways and the role of specific sodium channel subtypes (e.g., Nav1.7) for potential analgesic drug discovery.
• Toxin Mechanism Studies: Serves as a reference standard or active agent in research focused on the biochemistry and mode of action of marine and pufferfish toxins.
• Ion Channel Screening Assays: Employed in high-throughput screening (HTS) platforms to identify and characterize new compounds that interact with voltage-gated sodium channels.
• Biochemical Research: Used in ligand-binding studies and receptor mapping due to its high binding affinity for specific sites on sodium channels.
• Academic & Institutional Research: Supplied to universities and government labs for fundamental research in neurobiology, toxicology, and cellular physiology.

Basic Information

Item	Detail
Product Name	(8S)-4-o-Ethyltetrodotoxin
CAS No.	7724-40-5
Molecular Formula	C13H19N3O9
Molecular Weight	361.31 g/mol
Synonyms	4-O-Ethyltetrodotoxin; Ethyltetrodotoxin; 4-Ethoxy-9-azahypoxanthine derivative (of TTX); Tetrodotoxin 4-O-ethyl ether; TTX derivative; 4-O-Ethyl-TTX; (8S)-4-O-Ethyl-6,11-dideoxy-1,2,3,4,5,6,7,8,9,10,11-undecahydro-6,11-epiminodibenzo[a,e]cyclooctene-4,8,9,10-tetrol 4-ethyl ether
EINECS	Contact for details

Quality Control

Our (8S)-4-o-Ethyltetrodotoxin is produced and handled under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and structural confirmation via NMR and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.