Description

(8S)-4-Amino-4-Deoxytetrodotoxin is a potent and structurally complex neurotoxin derivative, primarily recognized for its role as a highly selective sodium channel blocker. This specificity makes it an invaluable tool compound for advanced neuroscience research and pharmacological studies. It is essential for researchers and developers in the pharmaceutical and life sciences sectors, particularly those investigating neuropathic pain mechanisms, ion channel function, and novel therapeutic targets.

Application

• Neuroscience Research: As a selective sodium channel inhibitor for studying neuronal signaling, action potentials, and channelopathies.
• Pharmacological Studies: Used as a reference standard and active agent in the development of novel analgesics and neuroprotective drugs.
• Toxicology & Safety Assessment: Employed as a calibrant and positive control in assays designed to detect and quantify tetrodotoxin and related analogs.
• Biochemical Reagent: Serves as a critical tool in electrophysiology experiments to block voltage-gated sodium channels in cell lines and tissue samples.
• Academic & Institutional Research: Fundamental for university and institutional labs exploring marine toxins, neurobiology, and cellular physiology.

Basic Information

Product Name	(8S)-4-Amino-4-Deoxytetrodotoxin
CAS No.	7724-38-1
Molecular Formula	C₁₁H₁₇N₅O₈
Molecular Weight	323.28 g/mol
Synonyms	4-Amino-4-deoxytetrodotoxin; 4-ADTTX; 4-Amino-4-deoxy-TTX; 4-Amino-4-deoxy-tetrodotoxin; 4-AD-TTX; Tetrodotoxin 4-amino-4-deoxy derivative; (8S)-4-Amino-4-deoxy-tetrodotoxin
EINECS	Contact for details

Quality Control

Our (8S)-4-Amino-4-Deoxytetrodotoxin is produced and handled under strict quality protocols suitable for research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere when possible and opened only in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.