Description

(+)-Camptothecin CAS NO 7689-03-4 is a potent, naturally occurring alkaloid that serves as a foundational scaffold for a critical class of anti-cancer therapeutics. Its core value lies in its unique mechanism of action as a topoisomerase I inhibitor, which disrupts DNA replication in rapidly dividing cells. This makes it an essential reference standard and key intermediate for pharmaceutical R&D, particularly in the development and quality control of chemotherapeutic agents like topotecan and irinotecan.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in the manufacturing of camptothecin-derived drugs.
• Active Pharmaceutical Ingredient (API) Intermediate: A critical starting material or intermediate in the synthesis of potent chemotherapeutic agents such as irinotecan and topotecan.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate mechanisms of topoisomerase I inhibition, apoptosis, and cancer cell proliferation.
• Anticancer Drug Discovery: Serves as a lead compound for the design, synthesis, and screening of novel analogs with improved efficacy and reduced toxicity profiles.
• Academic & Clinical Research: Utilized in university and hospital laboratories for fundamental oncology research and preclinical studies.

Basic Information

Product Name	(+)-Camptothecin
CAS No.	7689-03-4
Molecular Formula	C20H16N2O4
Molecular Weight	348.35 g/mol
Synonyms	Camptothecin, (S)-(+)-Camptothecin, (S)-Camptothecin, CPT, NSC 94600, Camptothecine, 4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
EINECS	231-674-7

Quality Control

Our (+)-Camptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Light yellow to yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	+40.0° to +43.0° (c=0.5 in CHCl3)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.