Description

o-Acetylcamptothecin is a semi-synthetic derivative of the potent natural product camptothecin, a key scaffold in oncology research. This compound matters as a critical intermediate for developing novel topoisomerase I inhibitors and exploring structure-activity relationships in anticancer drug discovery. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing next-generation chemotherapeutic agents and targeted cancer therapies.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of advanced camptothecin analogs and prodrug candidates with improved solubility or targeted delivery profiles.
• Oncology Research: Used in biochemical and cellular assays to study the mechanism of topoisomerase I inhibition and to evaluate antitumor activity.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aimed at modifying the camptothecin core to enhance efficacy and reduce side effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control in the production of related anticancer compounds.
• Bioconjugate Development: Utilized in the research and development of antibody-drug conjugates (ADCs) and other targeted cancer therapies.
• Apoptosis Research: Employed in studies investigating the induction of programmed cell death in various cancer cell lines.

Basic Information

Product Name	o-Acetylcamptothecin
CAS No.	7688-64-4
Molecular Formula	C22H18N2O5
Molecular Weight	390.39 g/mol
Synonyms	20-O-Acetylcamptothecin; (S)-20-Acetylcamptothecin; 20-Acetylcamptothecin; Camptothecin 20-acetate; 20-O-Acetyl-(S)-camptothecin; NSC 606985; CPTA; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-(acetyloxy)-, (4S)-
EINECS	Contact for details

Quality Control

Our o-Acetylcamptothecin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.