Description

n-ω-Nitro-L-Arginine Benzyl Ester P& is a protected derivative of the amino acid L-arginine, featuring a nitro group on the guanidine side chain and a benzyl ester protecting group on the carboxylate. This compound is a critical synthetic intermediate and research tool, valued for its role in the controlled synthesis and study of peptides and nitric oxide (NO) pathway modulators. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, biochemical research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the solid-phase and solution-phase synthesis of peptides containing modified arginine residues.
• Nitric Oxide (NO) Research: Used as a precursor or inhibitor analog in studies investigating the nitric oxide synthase (NOS) pathway and its physiological roles.
• Bioconjugation & Probe Development: Serves as a starting material for creating labeled probes or affinity tags for studying protein-protein interactions.
• Enzyme Substrate & Inhibitor Studies: Employed in biochemical assays to study the activity and inhibition of enzymes like trypsin-like proteases that recognize arginine.
• Academic & Industrial R&D: Fundamental research reagent in universities and corporate labs for exploring new chemical entities and biological mechanisms.
• Reference Standard: Used as a high-purity standard for analytical method development and quality control in peptide API manufacturing.

Basic Information

Product Name	n-ω-Nitro-L-Arginine Benzyl Ester P&
CAS No.	7672-27-7
Molecular Formula	C13H19N5O4
Molecular Weight	309.32 g/mol
Synonyms	Nω-Nitro-L-arginine benzyl ester; L-Nω-Nitroarginine benzyl ester; Benzyl Nω-nitro-L-argininate; NOARG-OBzl; Nω-Nitro-L-arginine O-benzyl ester; (S)-2-Amino-5-[(nitroamino)imino]pentanoic acid benzyl ester; Benzyl (2S)-2-amino-5-[(nitroamino)imino]pentanoate; Arg(NO2)-OBzl
EINECS	Contact for details

Quality Control

Our n-ω-Nitro-L-Arginine Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (IR, NMR). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.