Description

4-(Bromomethyl)Benzenesulfonyl Fluoride is a versatile bifunctional organic building block that combines a reactive benzylic bromide with a robust sulfonyl fluoride group. This dual functionality makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily used by R&D chemists and process development scientists in the life sciences industry for creating targeted covalent inhibitors and advanced chemical probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of covalent protease inhibitors and other targeted therapeutics.
• Chemical Biology Probe Development: Used in activity-based protein profiling (ABPP) to label and study enzyme active sites.
• Agrochemical Synthesis: Intermediate in the production of novel pesticides and herbicides with specific modes of action.
• Material Science: Monomer or cross-linking agent for the development of specialty polymers and functional surfaces.
• Sulfonyl Fluoride Chemistry: Serves as a precursor for generating a library of sulfonamide and sulfonate derivatives via sulfur(VI) fluoride exchange (SuFEx) click chemistry.

Basic Information

Product Name	4-(Bromomethyl)Benzenesulfonyl Fluoride
CAS No.	7612-88-6
Molecular Formula	C7H6BrFO2S
Molecular Weight	253.09 g/mol
Synonyms	α-Bromo-p-toluenesulfonyl Fluoride; 4-(Bromomethyl)phenylsulfonyl Fluoride; p-(Bromomethyl)benzenesulfonyl Fluoride; (4-Bromomethyl)benzenesulfonyl Fluoride; 1-(Bromomethyl)-4-(fluorosulfonyl)benzene; p-Bromomethylbenzenesulfonyl Fluoride; 4-Bromomethylbenzene-1-sulfonyl Fluoride; Benzenesulfonyl fluoride, 4-(bromomethyl)-
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)Benzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.