Description

p-Toluenesulfonylmethyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, primarily used as a key building block in organic synthesis. Its value lies in its ability to act as a methylene transfer reagent and a precursor for generating sulfonylmethyl carbanions, enabling the construction of complex molecular frameworks. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it facilitates the synthesis of active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of various drug candidates, particularly those requiring sulfone or methylene-sulfone functional groups.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and other crop protection agents.
• Organic Synthesis Reagent: Serves as a key reactant in Corey-Chaykovsky type reactions and for the preparation of sulfonylmethyl isocyanides (TosMIC chemistry).
• Polymer Chemistry: Employed as a modifier or cross-linking agent in the development of specialty polymers and resins.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of certain colorants and functional dyes.
• Chemical Research & Development: A valuable tool for academic and industrial R&D labs exploring new synthetic methodologies.

Basic Information

Product Name	p-Toluenesulfonylmethyl Chloride
CAS No.	7569-26-8
Molecular Formula	C8H9ClO2S
Molecular Weight	204.67 g/mol
Synonyms	Tosylmethyl Chloride; 4-Toluenesulfonylmethyl Chloride; α-Chloro-p-toluenesulfonylmethane; p-Tolylsulfonylmethyl Chloride; TosMIC Chloride; (Chloromethyl)(4-methylphenyl)sulfone; NSC 403914; Toluene-4-sulfonylmethyl chloride
EINECS	231-450-5

Quality Control

Our p-Toluenesulfonylmethyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.