Description

(8S,9S,13S,14S)-17-(2-Chloroethynyl)-3,17-Dimethoxy-13-Methyl-7,8,9,11,12,14,15,16-Octahydro-6H-Cyclopenta[A]Phenanthrene is a high-purity synthetic steroid derivative, serving as a critical advanced intermediate in pharmaceutical research and development. Its complex, functionalized steroidal core makes it an invaluable building block for the synthesis of novel therapeutic agents, particularly in the fields of endocrinology and oncology. This compound is essential for R&D chemists and process development scientists working on next-generation steroid-based pharmaceuticals and bioactive molecular probes.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel steroid hormone analogs and receptor modulators.
• Research & Development: Used in medicinal chemistry programs to explore structure-activity relationships (SAR) for new drug candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) with steroidal backbones.
• Biochemical Probes: Utilized in biological studies to investigate steroid receptor interactions and signaling pathways.

Basic Information

Item	Details
Product Name	(8S,9S,13S,14S)-17-(2-Chloroethynyl)-3,17-Dimethoxy-13-Methyl-7,8,9,11,12,14,15,16-Octahydro-6H-Cyclopenta[A]Phenanthrene
CAS No.	7548-44-9
Molecular Formula	C22H27ClO2
Molecular Weight	358.90 g/mol
Synonyms	17-(2-Chloroethynyl)-3,17-dimethoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene; 3,17-Dimethoxy-17-(2-chloroethynyl)-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene; 17α-(2-Chloroethynyl)-3-methoxy-17β-methoxyestra-1,3,5(10)-triene; A steroidal chloroacetylene intermediate; 3,17-Dimethoxy-17-(chloroethynyl)-13-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene
EINECS	Contact for details

Quality Control

Our (8S,9S,13S,14S)-17-(2-Chloroethynyl)-3,17-Dimethoxy-13-Methyl-7,8,9,11,12,14,15,16-Octahydro-6H-Cyclopenta[A]Phenanthrene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.