Description

Borrelidin is a potent, naturally occurring macrocyclic antibiotic and non-competitive inhibitor of threonyl-tRNA synthetase. Its unique mechanism of action makes it a critical tool compound for research into protein synthesis, angiogenesis, and cellular stress pathways. This high-purity material is essential for pharmaceutical R&D, academic research in microbiology and biochemistry, and as a reference standard in analytical laboratories.

Application

• Pharmaceutical Research & Development: As a lead compound or tool for studying anti-angiogenic, anti-bacterial, and anti-malarial agents.
• Biochemical Research: Used to inhibit threonyl-tRNA synthetase, enabling studies on protein synthesis, amino acid metabolism, and tRNA charging.
• Cell Biology & Oncology Studies: Investigated for its ability to induce apoptosis and inhibit proliferation in various cancer cell lines.
• Microbiology & Antibiotic Research: Serves as a reference standard for novel antibiotic discovery and resistance mechanism studies.
• Academic & Institutional Research: A key reagent for universities and research institutes exploring fundamental biological processes.
• Analytical Reference Standard: Used in HPLC, LC-MS, and NMR for method development, validation, and quality control of related products.

Basic Information

Product Name	Borrelidin
CAS No.	7184-60-3
Molecular Formula	C₂₇H₄₁NO₆
Molecular Weight	475.62 g/mol
Synonyms	Borrelidin; Antibiotic Borrelidin; NSC 501467; Threonyl-tRNA Synthetase Inhibitor; (-)-Borrelidin; (2E,4E,6R,8E,10E,12S,13R,14S,16R)-13-Ethyl-4,6,8,10,12,14,16-heptamethyl-3,17-dioxo-2,4,6,8,10,12,14,16-octadecaoctaenoic acid; 18-Cycloheptadeca-2,4,6,8,10,12,14,16-octaene-1,17-dione, 13-ethyl-4,6,8,10,12,14,16-heptamethyl-, (2E,4E,6R,8E,10E,12S,13R,14S,16R)-
EINECS	Contact for details

Quality Control

Our Borrelidin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support cGMP standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.