Description

4-Fluoro-2-Methylbenzenesulfonyl Chloride is a versatile and reactive organosulfur compound, serving as a key sulfonylation reagent in advanced organic synthesis. Its primary value lies in its ability to introduce the sulfonyl functional group, a critical step in creating molecules with specific biological or material properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides where the sulfonyl moiety enhances activity.
• Material Science Research: Employed in the development of specialty polymers, dyes, and liquid crystals that require sulfone linkages.
• Chemical Derivatization: Acts as a reagent for protecting groups or for introducing fluorescent or other tags in analytical chemistry and biochemistry.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs for the production of client-specific target molecules in medicinal chemistry programs.

Basic Information

Product Name	4-Fluoro-2-Methylbenzenesulfonyl Chloride
CAS No.	7079-48-3
Molecular Formula	C7H6ClFO2S
Molecular Weight	208.64 g/mol
Synonyms	2-Methyl-4-fluorobenzenesulfonyl chloride; 4-Fluoro-o-toluenesulfonyl chloride; p-Fluoro-o-toluenesulfonyl chloride; 1-Fluoro-4-methyl-2-sulfonylchloridobenzene; 4-Fluoro-2-methylphenylsulfonyl chloride; Benzenesulfonyl chloride, 4-fluoro-2-methyl-; 2-Methyl-4-fluorophenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 4-Fluoro-2-Methylbenzenesulfonyl Chloride adheres to stringent in-process controls and final batch testing to ensure high chemical purity and consistency. Quality is verified through analytical methods including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.