Description

3-(Trifluoromethyl)Benzenesulfonyl Chloride is a versatile and highly reactive organosulfur compound, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the electron-withdrawing trifluoromethyl group and the reactive sulfonyl chloride moiety, enabling precise chemical modifications. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and pesticides with enhanced efficacy and selectivity.
• Material Science: Used in the production of specialty polymers, dyes, and liquid crystal compounds.
• Chemical Research: A valuable reagent for introducing the 3-(trifluoromethyl)benzenesulfonyl group into complex molecules in medicinal and process chemistry.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed coupling reactions to form carbon-sulfur bonds.

Basic Information

Product Name	3-(Trifluoromethyl)Benzenesulfonyl Chloride
CAS No.	777-44-6
Molecular Formula	C7H4ClF3O2S
Molecular Weight	244.62 g/mol
Synonyms	m-(Trifluoromethyl)benzenesulfonyl chloride; α,α,α-Trifluoro-m-toluenesulfonyl chloride; 3-(Trifluoromethyl)phenylsulfonyl chloride; Benzenesulfonyl chloride, 3-(trifluoromethyl)-; m-Trifluoromethylbenzenesulfonyl chloride; 3-Trifluoromethylbenzene-1-sulfonyl chloride
EINECS	212-300-8

Quality Control

Our production of 3-(Trifluoromethyl)Benzenesulfonyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under dry conditions. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.