Description

2-(Trifluoromethyl)Benzenesulfonyl Chloride is a high-purity, reactive organosulfur intermediate essential for advanced chemical synthesis. Its core value lies in the trifluoromethyl and sulfonyl chloride functional groups, which enable precise molecular modifications to enhance the properties of target compounds. This product is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing sulfonamide-based active pharmaceutical ingredients (APIs), including protease inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group improves biological activity and environmental stability.
• Material Science: Serves as a precursor for functional polymers, dyes, and liquid crystals, imparting unique electronic and surface properties.
• Chemical Research & Development: A versatile reagent for introducing the 2-(trifluoromethyl)benzenesulfonyl moiety in medicinal chemistry and process development.
• Peptide Chemistry: Employed as a sulfonylation agent for protecting groups or for modifying amino acid side chains.

Basic Information

Product Name	2-(Trifluoromethyl)Benzenesulfonyl Chloride
CAS No.	776-04-5
Molecular Formula	C7H4ClF3O2S
Molecular Weight	244.62 g/mol
Synonyms	α,α,α-Trifluoro-o-toluenesulfonyl Chloride; 2-(Trifluoromethyl)benzene-1-sulfonyl chloride; o-(Trifluoromethyl)benzenesulfonyl Chloride; 2-Trifluoromethylbenzenesulfonyl Chloride; Benzenesulfonyl chloride, 2-(trifluoromethyl)-; o-Trifluoromethylphenylsulfonyl Chloride
EINECS	212-278-8

Quality Control

Our 2-(Trifluoromethyl)Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high chemical purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.