Description

Mesitylene-2-Sulfonyl Chloride CAS NO 773-64-8 is a specialized aromatic sulfonyl chloride derivative, serving as a high-value chemical intermediate in advanced organic synthesis. Its core value lies in its reactivity as a sulfonylation agent, enabling the introduction of the mesitylene-2-sulfonyl (Mts) protecting group, which is crucial for peptide synthesis and pharmaceutical research. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Peptide Synthesis: Used to introduce the mesitylene-2-sulfonyl (Mts) group as a temporary protecting group for amines, particularly in solid-phase peptide synthesis (SPPS).
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science: Precursor for synthesizing sulfonated polymers, dyes, and functional materials.
• Chemical Biology & Proteomics: Tool compound for modifying proteins and studying enzyme activity.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions to form carbon-sulfur bonds.

Basic Information

Item	Details
Product Name	Mesitylene-2-Sulfonyl Chloride
CAS No.	773-64-8
Molecular Formula	C9H11ClO2S
Molecular Weight	218.70 g/mol
Synonyms	2-Mesitylenesulfonyl chloride; Mesityl-2-sulfonyl chloride; 2,4,6-Trimethylbenzenesulfonyl chloride; Mts-Cl; 2,4,6-Trimethylphenylsulfonyl chloride; Mts chloride; 2-Mesitylenesulphonyl chloride; 2,4,6-Trimethylbenzenesulphonyl chloride
EINECS	212-250-1

Quality Control

Our Mesitylene-2-Sulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, IR and NMR for structural confirmation, and tests for specific impurities. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment. We support compliance with cGMP, ISO, and other relevant quality standards for research and production use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, strong oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Melting Point	64 - 68 °C
Water Content (KF)	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.