Description

Propanesulphonyl Fluoride is a versatile organosulfur fluorinating reagent with the CAS registry number 762-69-6. This compound is valued for its high reactivity as a sulfonyl fluoride precursor, enabling efficient chemical transformations in advanced synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs) and protease inhibitors.
• Chemical Proteomics & Bioconjugation: Used as a reactive handle in activity-based protein profiling (ABPP) and for covalent modification of proteins, leveraging the unique reactivity of the sulfonyl fluoride group.
• Agrochemical Synthesis: Serves as a precursor for sulfonylurea and other sulfonamide-class herbicides and pesticides.
• Material Science: Employed in the surface functionalization of polymers and nanomaterials to introduce sulfonyl fluoride groups for further coupling reactions.
• Organic Synthesis Reagent: Acts as an electrophile in nucleophilic substitution reactions to introduce the propanesulfonyl moiety into target molecules.
• Fluorine Chemistry: Utilized as a source of the sulfonyl fluoride functional group in the development of new fluorinated compounds with tailored properties.

Basic Information

Product Name	Propanesulphonyl Fluoride
CAS No.	762-69-6
Molecular Formula	C3H7FO2S
Molecular Weight	126.15 g/mol
Synonyms	1-Propanesulfonyl Fluoride; Propane-1-sulfonyl Fluoride; Propanesulfonyl Fluoride; 1-Propanesulfonic Acid Fluoride; NSC 401122; Propanesulfonic Acid Fluoride; Propylsulfonyl Fluoride
EINECS	212-096-4

Quality Control

Our Propanesulphonyl Fluoride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.