Description

2-Fluoroethanesulfonyl Chloride is a versatile and highly reactive organofluorine building block, essential for introducing the fluoroethylsulfonyl moiety into target molecules. Its primary value lies in its role as a key sulfonylation reagent, enabling the synthesis of sulfonamides and sulfonate esters with enhanced physicochemical properties. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and enzyme modulators.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the fluoroethylsulfonyl group contributes to biological activity and metabolic stability.
• Material Science: Employed in the modification of polymer surfaces and the creation of specialty monomers to impart specific chemical resistance or surface properties.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling proteins or other biomolecules, facilitating activity-based protein profiling (ABPP) and bioconjugation strategies.
• Ligand & Catalyst Development: Utilized in organometallic chemistry to synthesize novel ligands and catalysts with tailored electronic properties.
• Fluorine Chemistry Research: A fundamental reagent for exploring new methodologies in organofluorine chemistry and the construction of complex fluorinated architectures.

Basic Information

Product Name	2-Fluoroethanesulfonyl Chloride
CAS No.	762-68-5
Molecular Formula	C2H4ClFO2S
Molecular Weight	146.56 g/mol
Synonyms	2-Fluoroethanesulfonyl chloride; 2-Fluoroethylsulfonyl chloride; 2-Fluoroethane-1-sulfonyl chloride; Ethanesulfonyl chloride, 2-fluoro-; 1-Fluoro-2-chlorosulfonylethane; FESC; 2-Fluoroethyl sulfone chloride; 762-68-5
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoroethanesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA), including results for assay, identity, and impurity profiles (typically by GC, HPLC, and NMR), is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, it should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.