Description

3-Acetylbenzenesulfonyl Fluoride is a versatile and highly reactive aromatic sulfonyl fluoride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, where the sulfonyl fluoride group acts as a selective and efficient electrophile for sulfur(VI) fluoride exchange (SuFEx) click chemistry, and the acetyl moiety provides a handle for further derivatization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing protease inhibitors, covalent drugs, and novel materials through robust linkage chemistry.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of covalent protease inhibitors and other targeted therapeutics utilizing SuFEx chemistry.
• Agrochemical Synthesis: Building block for creating novel pesticides and herbicides with enhanced stability and bioactivity.
• Chemical Biology Probe Development: Used to create activity-based probes (ABPs) for labeling and studying enzyme activity in complex biological systems.
• Polymer and Material Science: Monomer or cross-linking agent for synthesizing specialty polymers, coatings, and functionalized surfaces.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions and as a protecting group or directing group in complex molecule assembly.
• Bioconjugation: Facilitates stable linkage of small molecules, dyes, or drugs to proteins, antibodies, or other biomolecules.

Basic Information

Product Name	3-Acetylbenzenesulfonyl Fluoride
CAS No.	709-60-4
Molecular Formula	C8H7FO3S
Molecular Weight	202.20 g/mol
Synonyms	1-(3-Fluorosulfonylphenyl)ethanone; 3-Acetylphenylsulfonyl Fluoride; m-Acetylbenzenesulfonyl Fluoride; 3-Acetylbenzenesulfonfluoride; 3-Acetylbenzene-1-sulfonyl Fluoride; 3-Acetylbenzenesulphonic Acid Fluoride; 3-Acetylbenzenesulfonylfluoride; 3'-Acetylbenzenesulfonyl Fluoride
EINECS	Contact for details

Quality Control

Every batch of 3-Acetylbenzenesulfonyl Fluoride is produced and tested under a strict quality management system to ensure consistency and reliability for your critical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.