Description

4-Trifluoromethoxytoluene is a versatile fluorinated aromatic building block characterized by its trifluoromethoxy and methyl substituents. This compound is valued for its unique electronic properties and stability, making it a critical intermediate in advanced chemical synthesis. It is primarily sought after by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core component in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart enhanced chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and functional group transformations to introduce the trifluoromethoxyphenyl moiety into target structures.
• Dye & Pigment Intermediate: Used in the production of high-performance, light-fast dyes and pigments for industrial applications.

Basic Information

Product Name	4-Trifluoromethoxytoluene
CAS No.	706-27-4
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	1-Methyl-4-(trifluoromethoxy)benzene; p-(Trifluoromethoxy)toluene; α,α,α-Trifluoro-p-cresol methyl ether; 4-Methylphenyl trifluoromethyl ether; 4-(Trifluoromethoxy)methylbenzene; p-Trifluoromethoxytoluene; Toluene, 4-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethoxytoluene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including GC, HPLC, and NMR to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring stringent material traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from strong acids and heat sources. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.420 - 1.430
Density (20°C)	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.