Description

3-Trifluoromethoxytoluene is a versatile fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its unique trifluoromethoxy group, which imparts enhanced metabolic stability, lipophilicity, and electronic properties to target molecules. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group improves biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals and organic semiconductors for display and electronic applications.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and functional group transformations to introduce the -OCF₃ moiety.
• Dye & Pigment Industry: Utilized in the synthesis of specialized fluorinated dyes and pigments that offer improved lightfastness and chemical resistance.

Basic Information

Product Name	3-Trifluoromethoxytoluene
CAS No.	705-44-2
Molecular Formula	C₈H₇F₃O
Molecular Weight	176.14 g/mol
Synonyms	1-Methyl-3-(trifluoromethoxy)benzene; m-(Trifluoromethoxy)toluene; 3-Methylphenyl trifluoromethyl ether; α,α,α-Trifluoro-m-cresol methyl ether; 3-(Trifluoromethoxy)toluene; m-Trifluoromethoxytoluene; Benzene, 1-methyl-3-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethoxytoluene is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical properties are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.25 g/mL
Refractive Index (n20D)	~1.42

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.