Description

3-Chloromethyl-Benzotrifluoride is a versatile and high-value fluorinated aromatic building block, essential for introducing the trifluoromethylphenyl moiety into complex molecular architectures. Its primary commercial value lies in its dual reactive sites—the chloromethyl group and the electron-deficient aromatic ring—enabling its use as a key intermediate in advanced synthesis. This compound is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the bioisosteric and metabolically stable benzotrifluoride group.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique properties such as chemical resistance, thermal stability, and altered solubility.
• Cross-coupling Reactions: Acts as an electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	3-Chloromethyl-Benzotrifluoride
CAS No.	705-29-3
Molecular Formula	C8H6ClF3
Molecular Weight	194.58 g/mol
Synonyms	α,α,α-Trifluoro-3-(chloromethyl)toluene; 3-(Chloromethyl)benzotrifluoride; 1-Chloromethyl-3-(trifluoromethyl)benzene; m-(Chloromethyl)benzotrifluoride; 3-(Trifluoromethyl)benzyl Chloride; (3-Trifluoromethylphenyl)methyl Chloride; m-Trifluoromethylbenzyl Chloride; Benzene, 1-(chloromethyl)-3-(trifluoromethyl)-
EINECS	211-885-3

Quality Control

Our 3-Chloromethyl-Benzotrifluoride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP or research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.30 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.