Description

3-Ethynyl-Alpha, Alpha, α-Trifluoro& CAS NO 705-28-2 is a high-purity, specialized fluorinated alkyne building block essential for advanced organic synthesis. Its unique structure, featuring both a reactive ethynyl group and a trifluoromethyl moiety, makes it a critical intermediate for introducing fluorine atoms into complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging fluorine's ability to improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides, herbicides, and fungicides where the trifluoromethyl group can enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and advanced fluorinated materials with unique surface properties.
• Ligand & Catalyst Development: Employed in organometallic chemistry to synthesize sophisticated ligands and catalysts for asymmetric synthesis and other catalytic processes.
• Fluorine-18 Radiochemistry: Potential precursor in Positron Emission Tomography (PET) tracer development, although specific radiochemical applications require specialized handling and facilities.
• Academic & Industrial R&D: A versatile reagent for method development and exploring new chemical spaces in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	3-Ethynyl-Alpha, Alpha, α-Trifluoro& CAS NO 705-28-2
CAS No.	705-28-2
Molecular Formula	C4HF3
Molecular Weight	118.05 g/mol
Synonyms	3-Ethynyl-α,α,α-trifluorotoluene; (Trifluoromethyl)phenylacetylene; 1-Ethynyl-4-(trifluoromethyl)benzene; 4-(Trifluoromethyl)phenylacetylene; 4-Ethynylbenzotrifluoride; 4-Trifluoromethylphenylacetylene; p-(Trifluoromethyl)phenylacetylene; α,α,α-Trifluoro-4-ethynyltoluene
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-Alpha, Alpha, α-Trifluoro& CAS NO 705-28-2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reliable and consistent performance in sensitive synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.