Description

Ethyl 2,2-Difluoro-2-m-Tolylacetate is a specialized fluorinated organic ester building block of significant interest in advanced synthetic chemistry. Its value lies in the unique reactivity imparted by the difluoromethyl group adjacent to the carbonyl, making it a versatile precursor for constructing complex molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly those requiring the incorporation of fluorine to modulate biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides where fluorine atoms enhance efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for specialty polymers with tailored surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions, nucleophilic substitutions, and other transformations to introduce difluorinated acetophenone motifs.
• Ligand and Catalyst Development: Utilized in the synthesis of novel chiral auxiliaries or catalyst frameworks for asymmetric synthesis.
• Fluorine Chemistry Research: A valuable substrate for studying the reactivity and stability of gem-difluoro compounds in academic and industrial R&D settings.

Basic Information

Product Name	Ethyl 2,2-Difluoro-2-m-Tolylacetate
CAS No.	698379-26-9
Molecular Formula	C11H12F2O2
Molecular Weight	214.21 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(3-methylphenyl)acetate; 2,2-Difluoro-2-(m-tolyl)acetic Acid Ethyl Ester; m-Tolyl(difluoro)acetic Acid Ethyl Ester; 3-Methyl-α,α-difluorobenzeneacetic Acid Ethyl Ester; Ethyl (3-Methylphenyl)difluoroacetate; Ethyl α,α-Difluoro-m-toluate; Acetic acid, 2,2-difluoro-2-(3-methylphenyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2,2-Difluoro-2-m-Tolylacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.