Description

3-Fluoro-4-Trifluoromethylbenzenesulfonyl Chloride is a high-value, multi-functional chemical intermediate essential for advanced synthesis. This compound is prized for its role as a versatile sulfonylation and sulfamoylation reagent, enabling the introduction of a highly fluorinated aromatic sulfonyl group. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients, including kinase inhibitors and herbicides.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science: Serves as a precursor for functionalized polymers and advanced materials requiring specific surface properties or chemical resistance.
• Chemical Research & Development: A critical reagent in organic synthesis for introducing the sulfonyl chloride moiety into complex molecules for further derivatization.
• Ligand and Catalyst Design: Employed in the creation of specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.

Basic Information

Product Name	3-Fluoro-4-Trifluoromethylbenzenesulfonyl Chloride
CAS No.	694472-01-0
Molecular Formula	C7H3ClF4O2S
Molecular Weight	262.61 g/mol
Synonyms	4-(Trifluoromethyl)-3-fluorobenzenesulfonyl chloride; 3-Fluoro-α,α,α-trifluoro-p-toluenesulfonyl chloride; 4-(Trifluoromethyl)-3-fluorophenylsulfonyl chloride; 3-Fluoro-4-trifluoromethylbenzenesulfonyl chloride; 1-Fluoro-2-(trifluoromethyl)-4-(chlorosulfonyl)benzene; 3-Fluoro-4-(trifluoromethyl)benzenesulfonyl chloride; 4-Chlorosulfonyl-2-fluorobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Trifluoromethylbenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.