Description

Tumor Necrosis Factor-α Protease Inhibitor-2 (TNF-α Protease Inhibitor-2) is a potent and selective small-molecule inhibitor designed to target the proteolytic activity associated with TNF-α signaling pathways. This compound is a critical research tool for investigating inflammatory cascades, cellular apoptosis, and immune regulation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for autoimmune diseases, chronic inflammation, and certain cancers.

Application

• Biomedical Research: A key reagent for in vitro and in vivo studies of TNF-α mediated signaling, inflammation, and cell death pathways.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening (HTS) and lead optimization for anti-inflammatory drug candidates.
• Mechanistic Studies: Enables the elucidation of specific protease functions and their role in disease models, including rheumatoid arthritis and inflammatory bowel disease (IBD).
• Academic & Institutional Labs: Supports fundamental research in immunology, molecular biology, and biochemistry departments.
• Biopharmaceutical Production: May be used in process development to study and control protease activity in cell culture systems.

Basic Information

Product Name	Tumor Necrosis Factor-α Protease Inhibitor-2
CAS No.	689284-12-6
Molecular Formula	C23H21N3O5S
Molecular Weight	451.50 g/mol
Synonyms	TAPI-2; TNF-α Protease Inhibitor 2; TNF-α Converting Enzyme Inhibitor, TACE Inhibitor II; (2R,3S)-3-(Formyl-hydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid [(2S,3R)-1-(N-hydroxyamino)-1-oxo-3-(2-thienylthio)-2-butanyl]amide; N-[(2R,3S)-3-[(Hydroxyamino)carbonyl]-2-(3-phenylpropyl)-1-oxobutyl]-β-alanine N-hydroxyamide, 3'-(2-thienylthio) derivative; CAS 689284-12-6
EINECS	Contact for details

Quality Control

Our Tumor Necrosis Factor-α Protease Inhibitor-2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.