Description

Iwp-2 CAS NO 686770-61-6 is a potent and selective small molecule inhibitor of the Wnt/β-catenin signaling pathway, a critical regulator of cell proliferation and differentiation. This compound is essential for researchers and developers targeting diseases driven by aberrant Wnt signaling, such as certain cancers and fibrotic disorders. It is primarily utilized in pharmaceutical R&D for drug discovery, preclinical studies, and as a crucial biochemical tool for pathway analysis in academic and industrial laboratories.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of novel oncology therapeutics.
• Preclinical Cancer Studies: Used in in vitro and in vivo models to investigate the efficacy of Wnt pathway inhibition against various carcinomas.
• Biochemical Pathway Analysis: A vital tool for elucidating the role of the Wnt/β-catenin pathway in cell signaling, stem cell biology, and tissue regeneration studies.
• High-Throughput Screening (HTS): Employed as a control compound in assay development and screening campaigns to identify new Wnt signaling modulators.
• Academic Research: Supports fundamental research in developmental biology, fibrosis, and other pathological conditions linked to Wnt signaling dysregulation.

Basic Information

Product Name	Iwp-2
CAS No.	686770-61-6
Molecular Formula	C₂₀H₁₄N₂O₄S
Molecular Weight	378.40 g/mol
Synonyms	IWP-2; IWP 2; IWP2; (2Z)-3-[(3,4-Dimethoxyphenyl)methylidene]-6-[(E)-2-phenylethenyl]-1,3-thiazolo[3,2-a]benzimidazol-2(3H)-one; 2(3H)-Thiazolo[3,2-a]benzimidazolone, 3-[(3,4-dimethoxyphenyl)methylene]-6-[(1E)-2-phenylethenyl]-; Wnt Pathway Inhibitor IWP-2; Porcupine Inhibitor IWP-2
EINECS	Contact for details

Quality Control

Our Iwp-2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.