Description

2,6-Difluoro-3-Iodopyridine is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a versatile intermediate for introducing functional complexity into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro-iodopyridine moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis, facilitating cross-coupling and other key reactions in fine chemical manufacturing.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers, due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags or molecular probes, leveraging the iodine atom for further functionalization via click chemistry or palladium-catalyzed reactions.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring precise halogenation patterns for structure-activity relationship (SAR) studies.

Basic Information

Product Name	2,6-Difluoro-3-Iodopyridine
CAS No.	685517-67-3
Molecular Formula	C5H2F2IN
Molecular Weight	256.98 g/mol
Synonyms	3-Iodo-2,6-difluoropyridine; 2,6-Difluoro-3-iodopyridine; Pyridine, 2,6-difluoro-3-iodo-; 685517-67-3; 3-Iodo-2,6-difluoropyridine; 2,6-Difluoro-3-iodo-pyridine
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-3-Iodopyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.