Description

(4-(Trifluoromethoxy)Phenyl)Methanesulfonyl Chloride is a high-purity, specialized organosulfur reagent featuring a trifluoromethoxy-substituted aromatic ring. This compound is a critical building block in modern synthetic chemistry, valued for its role in introducing the sulfonyl chloride functional group into complex molecular architectures. It is primarily utilized by research and development chemists and process scale-up teams within the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in creating novel herbicides and fungicides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique surface properties.
• Chemical Biology Probes: Employed in the design of activity-based probes and covalent inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	(4-(Trifluoromethoxy)Phenyl)Methanesulfonyl Chloride
CAS No.	683813-55-0
Molecular Formula	C8H6ClF3O3S
Molecular Weight	274.64 g/mol
Synonyms	4-(Trifluoromethoxy)benzenemethanesulfonyl chloride; p-(Trifluoromethoxy)phenylmethanesulfonyl chloride; 1-[(4-Trifluoromethoxyphenyl)methanesulfonyl] chloride; (4-Trifluoromethoxyphenyl)methanesulfonyl chloride; α-Toluenesulfonyl chloride, 4-(trifluoromethoxy)-; [4-(Trifluoromethoxy)phenyl]methanesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of (4-(Trifluoromethoxy)Phenyl)Methanesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure consistency and reliability for your critical synthetic steps. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC purity, NMR, and MS data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.