Description

Cyclopropane, 1-Bromo-2-Fluoro-3-Methyl-, (1R,2S,3R)-Rel- (9Ci) is a high-purity, stereochemically defined fluorinated cyclopropane building block. This compound is a critical chiral intermediate for the synthesis of advanced pharmaceutical candidates and agrochemicals, offering precise control over molecular geometry. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorinated cyclopropane moiety can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a specialized monomer or precursor for developing novel fluorinated polymers and advanced materials with unique properties.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and biological pathways due to its stable, three-dimensional structure.

Basic Information

Item	Details
Product Name	Cyclopropane, 1-Bromo-2-Fluoro-3-Methyl-, (1R,2S,3R)-Rel- (9Ci)
CAS No.	681536-32-3
Molecular Formula	C4H6BrF
Molecular Weight	153.00 g/mol
Synonyms	(1R,2S,3R)-1-Bromo-2-fluoro-3-methylcyclopropane; rel-(1R,2S,3R)-1-Bromo-2-fluoro-3-methylcyclopropane; 1-Bromo-2-fluoro-3-methylcyclopropane (stereoisomer); Fluorinated Bromocyclopropane Derivative; Bromofluoromethylcyclopropane; Chiral Bromo-Fluoro Cyclopropane Building Block
EINECS	Contact for details

Quality Control

Our Cyclopropane, 1-Bromo-2-Fluoro-3-Methyl-, (1R,2S,3R)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by GC or HPLC, to ensure high stereochemical and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral GC/HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.