Description

5-(2,5-Dioxo-Pyrrolidin-1-Yl)-Naphthalene-1-Sulfonyl Chloride is a specialized organic intermediate featuring a reactive sulfonyl chloride group and a maleimide (pyrrolidinedione) moiety. This bifunctional structure makes it a valuable building block for the synthesis of complex molecules, particularly in the creation of bioconjugates and functionalized polymers. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and life sciences sectors for developing targeted drug delivery systems, diagnostic agents, and advanced materials.

Application

• Bioconjugation Reagent: Used to covalently link proteins, peptides, or antibodies to other molecules (e.g., drugs, dyes, polymers) via amine groups, leveraging the maleimide-thiol or amine-sulfonyl chloride coupling chemistries.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and antibody-drug conjugates (ADCs) for targeted cancer therapies.
• Polymer Functionalization: Employed to introduce reactive sites onto polymer backbones, enabling the creation of smart materials, hydrogels, and surface coatings with specific biological or chemical functionalities.
• Diagnostic Probe Synthesis: Utilized in the preparation of fluorescent or radioactive probes for imaging and diagnostic applications in biomedical research.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker to connect two different biomolecules or materials, forming stable bridges for assay development or material science.
• Chemical Biology Research: A critical tool for labeling, immobilizing, or modifying biomolecules to study protein function, interactions, and cellular pathways.

Basic Information

Product Name	5-(2,5-Dioxo-Pyrrolidin-1-Yl)-Naphthalene-1-Sulfonyl Chloride
CAS No.	681260-22-0
Molecular Formula	C₁₄H₁₀ClNO₄S
Molecular Weight	323.75 g/mol
Synonyms	1-Naphthalenesulfonyl chloride, 5-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-; 5-(2,5-Dioxopyrrolidin-1-yl)naphthalene-1-sulfonyl chloride; 1,5-NDSC; 5-Maleimido-1-naphthalenesulfonyl chloride; N-(1-Sulfochloridonaphthyl)maleimide; Maleimidonaphthalene sulfonyl chloride; 5-Maleimidyl-1-naphthalenesulfonyl chloride; N-(1-Sulfonylchloridonaphthyl)-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our 5-(2,5-Dioxo-Pyrrolidin-1-Yl)-Naphthalene-1-Sulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive bioconjugation and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) with detailed specifications are provided to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.