Description

4-Fluoro-3-Methyl-1H-Pyrazole-5-Carboxylic Acid is a high-purity fluorinated pyrazole derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique fluorine-substituted heterocyclic structure imparts desirable biological activity and metabolic stability. Pharmaceutical, agrochemical, and specialty chemical R&D teams need this material to synthesize next-generation compounds targeting a range of therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with specific electronic or photophysical properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.
• Academic & Industrial R&D: Utilized in research laboratories for methodological studies and the exploration of new chemical spaces in medicinal and synthetic chemistry.

Basic Information

Product Name	4-Fluoro-3-Methyl-1H-Pyrazole-5-Carboxylic Acid
CAS No.	681034-58-2
Molecular Formula	C5H5FN2O2
Molecular Weight	144.10 g/mol
Synonyms	4-Fluoro-3-methyl-1H-pyrazole-5-carboxylic acid; 3-Methyl-4-fluoropyrazole-5-carboxylic acid; 5-Carboxy-4-fluoro-3-methyl-1H-pyrazole; 4-Fluoro-3-methyl-1H-pyrazole-5-carboxylic acid; 1H-Pyrazole-5-carboxylic acid, 4-fluoro-3-methyl-; 681034-58-2; 4-Fluoro-3-methylpyrazole-5-carboxylic acid; 3-Methyl-4-fluoro-1H-pyrazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methyl-1H-Pyrazole-5-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.