Description

3-(Pyridine-2-Carbonyl)-Benzenesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its unique bifunctional structure, combining a pyridine-carbonyl moiety with a benzenesulfonyl chloride group, makes it an invaluable reagent for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition via sulfonamide formation.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of specialty polymers and functional materials requiring sulfonated or pyridine-based monomers.
• Chemical Biology Probes: Enables the creation of activity-based probes and affinity labels for studying protein function and interaction.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-scale commercial batches.
• Academic & Industrial R&D: Essential reagent for methodological development in organic chemistry and exploratory synthesis projects.

Basic Information

Product Name	3-(Pyridine-2-Carbonyl)-Benzenesulfonyl Chloride
CAS No.	680618-23-9
Molecular Formula	C13H8ClNO3S
Molecular Weight	293.72 g/mol
Synonyms	2-(3-Chlorosulfonylbenzoyl)pyridine; 3-(2-Pyridinylcarbonyl)benzenesulfonyl chloride; 3-(Pyridine-2-carbonyl)benzene-1-sulfonyl chloride; 3-(2-Pyridylcarbonyl)benzenesulfonyl chloride; 2-(3-Chlorosulfonylbenzoyl)pyridine; 3-(Pyridine-2-carbonyl)phenylsulfonyl chloride; 3-(2-Pyridinecarbonyl)benzenesulfonyl chloride; 3-(Pyridin-2-ylcarbonyl)benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-(Pyridine-2-Carbonyl)-Benzenesulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.