Description

4-Phenyl-5-(Trifluoromethyl)Thiophene-3-Sulfonyl Chloride is a high-value, multi-functional chemical building block prized for its unique trifluoromethyl and sulfonyl chloride functional groups. This compound is essential for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its structure imparts desirable properties like metabolic stability and enhanced lipophilicity. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a building block for developing functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the design of activity-based probes and covalent inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a sulfonamide or sulfonate moiety.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable production of complex molecules.

Basic Information

Product Name	4-Phenyl-5-(Trifluoromethyl)Thiophene-3-Sulfonyl Chloride
CAS No.	680215-52-5
Molecular Formula	C11H6ClF3O2S2
Molecular Weight	326.74 g/mol
Synonyms	3-Thiophenesulfonyl chloride, 4-phenyl-5-(trifluoromethyl)-; 4-Phenyl-5-(trifluoromethyl)thiophene-3-sulfonyl chloride; 5-(Trifluoromethyl)-4-phenylthiophene-3-sulfonyl chloride; 4-Phenyl-5-trifluoromethylthiophene-3-sulfonyl chloride; 4-Phenyl-5-(trifluoromethyl)-3-thiophenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 4-Phenyl-5-(Trifluoromethyl)Thiophene-3-Sulfonyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent lot-to-lot performance. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.