Description

3(R)-Fluoropyrrolidine is a high-value, chiral fluorinated heterocyclic building block essential for modern pharmaceutical and agrochemical research. Its core value lies in introducing a fluorine atom and a rigid pyrrolidine scaffold into target molecules, which can dramatically improve metabolic stability, bioavailability, and binding affinity. This compound is critically needed by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, especially in CNS disorders, oncology, and antiviral therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & Bioisosteres: The fluoropyrrolidine ring is a common proline bioisostere in the design of peptide-based therapeutics and protease inhibitors.
• Material Science Research: Investigated as a monomer or functional additive for creating specialty polymers with unique properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	3(R)-Fluoropyrrolidine
CAS No.	679431-51-7
Molecular Formula	C4H8FN
Molecular Weight	89.11 g/mol
Synonyms	(R)-3-Fluoropyrrolidine; (3R)-Fluoropyrrolidine; (R)-3-Fluoropyrrolidine Hydrochloride (common salt form); 3R-Fluoropyrrolidine; Pyrrolidine, 3-fluoro-, (3R)-; Fluoropyrrolidine, (R)- isomer; (R)-(-)-3-Fluoropyrrolidine; UNII-9F8V3W71KJ
EINECS	Contact for details

Quality Control

Our 3(R)-Fluoropyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for advanced research and development. We provide comprehensive analytical data including chiral purity (enantiomeric excess) and chemical purity determined by GC, HPLC, and NMR. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and specific rotation are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.