Description

2-Bromo-4-Fluoro-5-Iodotoluene is a high-value, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and iodine substituents on a toluene backbone, makes it a versatile precursor for constructing complex molecules via selective cross-coupling reactions. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the halogen pattern can influence biological activity.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Sonogashira couplings, allowing for the sequential introduction of diverse functional groups.
• Chemical Synthesis: Employed in academic and industrial R&D for method development and the synthesis of complex, polyfunctionalized aromatic compounds.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Bromo-4-Fluoro-5-Iodotoluene
CAS No.	677777-56-9
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	1-Bromo-2-fluoro-4-iodo-5-methylbenzene; 2-Bromo-4-fluoro-1-iodo-5-methylbenzene; 5-Bromo-3-fluoro-4-iodotoluene; Toluene, 2-bromo-4-fluoro-5-iodo-; 2-Bromo-4-fluoro-5-iodo-1-methylbenzene; 4-Fluoro-2-bromo-5-iodotoluene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-Fluoro-5-Iodotoluene is produced and analyzed under strict quality management protocols to ensure consistency and high purity suitable for research and development applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to meet the exacting standards of the fine chemical industry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.