Description

2-Fluoropyridine-5-Carboxaldehyde is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of an aldehyde functional group and a fluorine atom on the pyridine ring, enabling precise molecular construction for complex targets. This compound is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Employed in the synthesis of functionalized polymers and organic electronic materials.
• Cross-Coupling Reactions: The aldehyde group is amenable to further transformation, making it useful in Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorine substitution on the reactivity and properties of heterocyclic systems.

Basic Information

Product Name	2-Fluoropyridine-5-Carboxaldehyde
CAS No.	677728-92-6
Molecular Formula	C6H4FNO
Molecular Weight	125.10 g/mol
Synonyms	5-Formyl-2-fluoropyridine; 2-Fluoro-5-formylpyridine; 2-Fluoro-5-pyridinecarboxaldehyde; 2-Fluoropyridine-5-carbaldehyde; 5-Aldehyde-2-fluoropyridine; Pyridine, 2-fluoro-5-formyl-; 677728-92-6
EINECS	Contact for details

Quality Control

Our 2-Fluoropyridine-5-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.